Pregnancy – Leptin, Vitamin B12 and Type 2 diabetes

We know that pregnancy is a crucial period when the expectant mom is basically caring not only for herself but her baby as well.


Previous research found that mothers with low level of Vitamin B12 usually had a higher Body Mass Index, leading to greater risk of giving birth to babies with low birth weights and high cholesterol levels. Not only that, these children also develop greater insulin resistance during childhood, an important factor for Type 2 diabetes.

Recently, a research study has been released linking Vitamin B12 deficiency could lead to increased risk of the child’s risk of developing Type 2 diabetes.

Why is this so?

Basically this link was established when the researchers were studying the effects of leptin, which is a hormone produced by the body’s fat cells. After eating, the brain triggers the production of leptin. causing its level to rise in the body. The purpose of leptin is to signal the “full” feeling after eating.

Researchers found that babies born to mothers having deficiencies in Vitamin B12 had higher levels of leptin. There seems to be some sort of metabolic changes that bring about this high level to be the ‘normal’ level now for the babies. This results in the babies developing leptin resistance – not feeling of the “fullness” – leading to the babies continued craving for food, overeating, leading to increased risk of insulin resistance and subsequently Type 2 diabetes.

The researchers postulate 2 explanations for the difference in leptin levels.
1. Vitamin B12 deficiency could lead to accumulation of fat in the fetus and hence increased level of leptin hormone.

2. Vitamin B12 deficiency causes chemical changes to placental genes that produce leptin, increasing levels of leptin hormone.

The 1st explanation is deemed more likely. However with either case, the increased level of leptin is now the norm for the baby – a case of leptin resistance.

Vitamin B12 is found in meat and fish and so are recommended as regular dietary intake for pregnant moms. For non-meat eaters, Vitamin B12 supplementation is particularly important to prevent anemia and maintain healthy brain function. Vitamin B12 is only found in very small amount in dairy products and eggs and even more rare in plants as food source.

Isotonix Advanced B Complex or Isotonix Activated B Complex are great choice for Vitamin B12 supplementation. Taken in isotonic formulation, the supplements are rapidly absorbed into the blood stream within minutes, ensuring highest efficacy not found in other formulations.

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